How do you test skin creams?
In our development department we work in three steps. When we test the effectiveness of a new ingredient, we use identical skin cell cultures for the first step—that is, cell cultures which are also present in the layers of skin. For the second step, we test on “artificial skin.” This skin is cultivated from human skin cells and is almost identical in its composition. We can even simulate environmental aging, in which we expose this skin to UV light. Like human skin, it is made up of three layers: subcutaneous tissue, the epidermis and the dermis. In the field of medicine, these artificial skin layers are already being implanted for some time now in severe burn patients. We use this skin to test the compatibility of creams.
When these two steps are successfully concluded and a positive effect is clearly proven, we can follow up with human testing. Next to artificial skin, there exists a whole battery of other tests to check compatibility. Testing on nature is useful, for example—without any animal testing—on a hen’s egg. A thin membrane exists between the shell and the egg white, whose components are similar to human skin.
What happens when an anti-aging cream is applied to young skin?
It is neither bad nor particularly effective. Creams for mature skin contain ingredients which are ideal for older skin. Because young skin has other needs, these ingredients achieve little. Skin simply dispenses of that which it does not need.
Thank you very much for talking with us, Dr. Waldmann-Laue.